Comparative polygenic predispositions of treatment-resistant depression in East Asian and European populations.

ABSTRACT: Large-scale genetic studies of treatment-resistant depression (TRD) have been performed majority on European ancestry cohorts, potentially missing important population-specific biological insights. Understanding the genetic predisposition for TRD across populations could provide insights for etiologic heterogeneity. Conducting a cohort study of 106,796 unrelated participants using Taiwan Biobank (TWBB), we investigated the association of polygenic score (PGS) with the development of TRD among patients with depression and explore the concordance of the PGS association between East Asian and European populations. Three binary outcomes were defined, including TRD vs. non-major depressive disorder (MDD), treatment responsive MDD (trMDD) vs. non-MDD, and TRD vs. trMDD. Six PGSs belong to person

SUBMITTER: Cheng CF 

PROVIDER: S-EPMC12932758 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature