FOXK1 induced upregulation of KIF20A promotes hepatocellular carcinoma progression via Wnt/β-Catenin/EMT signaling.

ABSTRACT: Liver cancer ranks sixth in incidence and third in mortality worldwide, with hepatocellular carcinoma (HCC) accounting for 90% of cases. Kinesin family genes (KIFs) have been implicated in HCC progression, but their specific roles remain unclear. Here, using multiple transcriptomic datasets and machine learning, we systematically screened KIF genes in HCC and identified nine key differentially expressed KIFs (KIF3A, KIF3B, KIF5B, KIF11, KIF13A, KIF13B, KIF20A, KIFC3, KLC2) as diagnostic biomarkers. A logistic regression model showed excellent diagnostic accuracy (AUC = 0.992) in the GSE121248 dataset. Six genes (KIF3A, KIF5B, KIF11, KIF13B, KIF20A, KLC2) were validated in TCGA, several correlating with prognosis. Notably, KIF20A was an independent prognostic factor, validated across cohort

SUBMITTER: Liu J 

PROVIDER: S-EPMC12932808 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature