Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [¹⁸F]PI-2620 PET.

ABSTRACT:

Introduction

Progressive supranuclear palsy (PSP), a 4-repeat tauopathy, can be visualized using [¹⁸F]PI-2620 tau positron emission tomography (PET). However, the value of sequential [¹⁸F]PI-2620 imaging for tracking tau accumulation during the disease course has not yet been investigated.

Methods

Twenty-three PSP patients underwent two [¹⁸F]PI-2620 PET scans (interval: 21.4 ± 4.3 months) and were compared to cross-sectional data from 25 healthy controls. Regional volume of distribution ratio values were analyzed for longitudinal tau changes, clinical correlations, and network-based propagation. Post mortem analyses examined neuronal density and AT8 tau pathology.

Results

Subcortical tau PET signals increased, strongest in the globus p

SUBMITTER: Gnorich J 

PROVIDER: S-EPMC12932912 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature