Risk factors for progression from <i>Clostridioides difficile</i> colonization (NAAT+/toxin-) to infection (toxin+) following symptomatic retesting.

ABSTRACT:

Objective

To identify host and clinical risk factors contributing to the development of Clostridioides difficile infection (CDI) among colonized patients.

Design

Retrospective, matched case-control study.

Setting

Duke University Health System, including 3 hospitals and affiliated outpatient clinics.

Participants

Adult patients who underwent ≥2 two-step C. difficile tests (nucleic acid amplification test (NAAT) followed by toxin enzyme immunoassay) between 03/15/2020-12/31/2023. Cases were patients with C. difficile colonization (NAAT+/toxin-) who converted to CDI (NAAT+/toxin+) within 90 days; controls were colonized patients who remained toxin-negative. Cases were matched to controls by date of index testing (±1 year).

Methods

Data

SUBMITTER: Chang S 

PROVIDER: S-EPMC12932920 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature