Plasma p-tau217 for Alzheimer's disease diagnosis: a memory clinic implementation approach.

ABSTRACT:

Introduction

Plasma phosphorylated tau at threonine 217 (p-tau217) has shown excellent diagnostic performance for Alzheimer's disease (AD), yet real-world validation and implementation pathways remain limited. This study assessed its clinical applicability and proposed a practical workflow for memory clinics.

Methods

Plasma p-tau217, p-tau181, and neurofilament light chain (NfL) were quantified in consecutive patients referred for cognitive assessment. Cerebrospinal fluid (CSF) amyloid beta (Aβ) 42/40 defined amyloid (A) status, and final etiological diagnoses were reached through multidisciplinary consensus integrating clinical, neuropsychological, and metabolic imaging data.

Results

Among 163 patients (mean age 69.3 ± 7.4 years, 52% female), plasma p-tau217 distingu

SUBMITTER: Brodini G 

PROVIDER: S-EPMC12932973 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature