ST-Segment Elevation Myocardial Infarction Following Adalimumab Initiation in a Young Adult.

ABSTRACT:

Background

Tumor necrosis factor alpha inhibitors have transformed management of autoimmune diseases, but cardiovascular safety profile of these diseases remains an area of investigation.

Case summary

A 39-year-old woman with rheumatoid arthritis presented with an ST-segment elevation myocardial infarction 3 weeks after initiating adalimumab therapy. Coronary angiography revealed a long thrombus in the mid left anterior descending coronary artery with preserved TIMI flow grade 3 and no coronary stenosis. A multidisciplinary team elected to pursue conservative management with glycoprotein IIb/IIIa inhibition (tirofiban) without stent placement given the patient's young age, absence of atherosclerotic plaque, and normal right and circumflex coronary arteries. Repeat angiograph

SUBMITTER: Harfoush A 

PROVIDER: S-EPMC12932987 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature