DNA Origami-Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity.

ABSTRACT: Chirality refers to handedness as left- or right-handed form of a molecule or molecular construct by synthesis or self-assembly. In biology, chirality plays critical roles in determining the structures and functions of biomolecules such as proteins. In this study, we demonstrated that structural chirality generated by patterning multiple cell surface protein biomarker-binding aptamers on a tubular-shaped DNA origami ("DNA tube") can realize differentness in cellular interaction, nanostructure uptake, cancer drug delivery, and consequent cell killing. Formation of the DNA tube and its ability to arrange external elements into left- or right-handed form have been characterized by gel electrophoresis, atomic force microscopy, and transmission electron microscopy. Our fluorescence-based cell e

SUBMITTER: Song T 

PROVIDER: S-EPMC12933013 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature