Distinct impact of PI(4)P flux on PI(4,5)P₂ steady states and oscillations.

ABSTRACT: Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P₂] regulates indispensable processes such as exocytosis, endocytosis, and actin cytoskeleton remodeling in eukaryotic cells. Since phosphatidylinositol 4-phosphate [PI(4)P] has long been regarded as the primary precursor of PI(4,5)P₂, perturbing PM PI(4)P is expected to impact the dynamics of PM PI(4,5)P₂. Yet, recent evidence suggests that PM PI(4)P has a limited role in the synthesis and function of PI(4,5)P₂. In this paper, we address this puzzling discrepancy by studying the collective dynamics of PM PI(4)P and PI(4,5)P₂. Leveraging live-cell imaging, we observed periodic traveling waves of PI(4)P on the PM of mast cells, challenging the notion that this precursor

SUBMITTER: Xu XJ 

PROVIDER: S-EPMC12933082 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature