Nutrigenomic profiling identifies ZIP10 (<i>SLC39A10</i>) as a regulator of erythroid zinc homeostasis with genetic associations to anemia risk.

ABSTRACT: Erythroid progenitors undergo dynamic morphological changes and robust heme biosynthesis during differentiation. Zinc is essential for erythropoiesis, yet the mechanisms linking zinc availability to heme biosynthesis and anemia risk remain unclear. This study aimed to define zinc-responsive pathways in differentiating erythroid progenitors and to evaluate the translational relevance of SLC39A10 (ZIP10) genetic variants to hematological health. To elucidate the molecular basis of zinc's role in erythropoiesis, we performed transcriptomic profiling of zinc-restricted G1E-ER4 cells during differentiation and compared it to iron chelation and δ-aminolevulinic acid dehydratase inhibition. Zinc deficiency uniquely enriched genes involved in not only heme biosynthesis but cellular m

SUBMITTER: Kim J 

PROVIDER: S-EPMC12933087 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature