Mfsd2a is important for maintaining epidermal homeostasis.

ABSTRACT: The skin epidermis is a multilayered lipid rich organ completely reliant on exogenous delivery and uptake of the essential fatty linoleate for the synthesis of acylceramides required for barrier function. Disruption of the epidermal skin barrier is a common clinical feature for prevalent diseases such as atopic dermatitis and psoriasis. The granulosum layer of the epidermis contains specialized secretory keratinocytes that synthesize and secrete lamellar bodies (LB), making it likely that this epidermal layer has a high demand for phosphatidylcholine. While the pathway for acylceramide biosynthesis and roles in barrier formation has been largely elucidated, the mechanisms by which keratinocytes acquire phospholipid for the demands of lipid barrier maintenance and repair are not entirely un

SUBMITTER: Wong BH 

PROVIDER: S-EPMC12933103 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature