Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.

ABSTRACT: The relationship between age-related cognitive changes and cortical macrostructural properties [i.e. cortical thickness (CTh)] has been extensively studied. However, less is known about the relationship with cortical microstructural characteristics [i.e. cortical mean diffusivity (cMD)] even though these are sensitive to preclinical phases of Alzheimer's disease. We studied a sample of 964 cognitively healthy adults (age: 40-82 years; 52% females) with available structural and diffusion MRI data. The preclinical Alzheimer's cognitive composite was used as the cognition measure, and plasma concentrations of neurodegenerative-related (i.e. phosphorylated tau 181 and neurofilament light) and inflammatory (i.e. high-sensitivity C-reactive protein) biomarkers were assessed, together with apolip

SUBMITTER: Perera-Cruz O 

PROVIDER: S-EPMC12933213 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature