Efficacy and Safety of Tirzepatide in Japanese Participants With Obesity: A Subpopulation Analysis of the SURMOUNT-1 Trial.

ABSTRACT:

Objective

This prespecified subpopulation analysis aimed to assess the efficacy and safety of once-weekly tirzepatide versus placebo alongside lifestyle intervention in Japanese adults with obesity or overweight.

Methods

Data from 102 Japanese adults in the SURMOUNT-1 trial with BMI ≥ 30 kg/m² or ≥ 27 kg/m² and ≥ 1 weight-related comorbidity were analyzed. Coprimary endpoints were mean percent change in body weight and the proportion of participants who achieved ≥ 5% body weight reduction at week 72.

Results

Participants in the tirzepatide 5-, 10-, and 15-mg groups had a statistically significantly greater (all p < 0.001) least squares mean (standard error) percent change in body weight compared with those in the placebo group: -12.0% (1.7%), -22

SUBMITTER: Ishigaki Y 

PROVIDER: S-EPMC12933229 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature