Bronchiectasis in children: a systematic review of cytokine profile, immune cell phenotypes and microbiota in bronchoalveolar lavage fluid.

ABSTRACT:

Background

Paediatric noncystic fibrosis bronchiectasis (NCFB) is a chronic respiratory condition characterised by airway infection, chronic inflammation, mucociliary dysfunction and structural lung damage. Emerging evidence highlights the importance of the local immune response and microbial environment in driving disease progression.

Objectives

This systematic review aimed to summarise contemporary evidence on bronchoalveolar lavage (BAL)-derived cytokine levels, immune cell phenotypes and microbiota in paediatric NCFB, with a focus on their role in disease pathogenesis, phenotype classification and potential to inform targeted interventions.

Methods

The review followed PRISMA guidelines and was registered with PROSPERO (CRD42024520391). Six electronic databases wer

SUBMITTER: Thomsen CMK 

PROVIDER: S-EPMC12933260 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature