Nickel-Catalyzed Aryl Group Interconversion: A Non-Equilibrium Strategy for Aryl Nitrile Synthesis.

ABSTRACT: Cross-electrophile coupling has become a powerful strategy for the construction of C-C bonds by linking two distinct electrophiles under metal catalysis. In contrast, aryl group interconversion reactions based on ligand exchange processes enable the direct swapping of aromatic groups between electrophilic partners, allowing the interconversion of different functional groups. Although these approaches can transform inexpensive substrates into high-value aromatic products, their inherent reversibility often requires excess reagents and relies on strong electronic bias between partners. Here, we describe a nickel-catalyzed aryl group interconversion between aromatic esters and 2-cyanopyridine. The process is driven by a decarbonylative ether formation step, which provides an irreversible path

SUBMITTER: Tanaka H 

PROVIDER: S-EPMC12933324 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature