Long-term natural history of thyroid peroxidase antibodies in a population-based cohort: Findings from 18 years of follow-up in Tehran Thyroid Study (TTS).

ABSTRACT:

Background

Thyroid peroxidase antibody (TPOAb) is considered a highly sensitive marker of autoimmune thyroid diseases (AITD). Limited longitudinal data exist regarding its long-term natural history in the general population. This study aimed to assess risk factors for TPOAb positivity and its 18-year prevalence, incidence, trajectories, and projected prevalence for the year 2030 in a population-based cohort.

Methods

A total of 5,438 adults were recruited at first visit (1999-2002) and followed across four subsequent visits up to 2018 in the iodine-sufficient population-based Tehran Thyroid Study (TTS). The age- and sex-standardized prevalence of TPOAb positivity was calculated, and the projected prevalence in 2030 was estimated using Poisson Generalized Linear Mixed Model (P

SUBMITTER: Tarighat-Payma M 

PROVIDER: S-EPMC12933471 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature