Synthesis of Antimicrobial Quinoline Derivatives Enabled by Synergistic Pd/Enamine Catalysis: Experimental and Computational Study.

ABSTRACT: An intermolecular addition of acetophenone derivatives to unactivated alkenes was developed through Pd-(II)/amine cooperative catalysis. This dual catalytic system functions by activating the amide-containing alkene via Pd-(II) coordination while simultaneously enhancing the nucleophilicity of the α-carbon of acetophenones through enamine catalysis, thereby facilitating the C-C bond-forming reaction. Five quinoline-based amide derivatives were designed and synthesized to explore their potential as biologically active agents. The synthesized compounds were structurally characterized using the standard NMR technique and subsequently evaluated for their antimicrobial activity against a panel of pathogenic bacterial and fungal strains. The five derivatives exhibited significant inhibitory effe

SUBMITTER: Sayed M 

PROVIDER: S-EPMC12933488 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature