Exploring Bayesian adaptive designs in multi-arm randomized controlled trials with a patient preference arm.

ABSTRACT: Clinical trial design efficiency is often defined as a design using the fewest subjects to achieve the trial goal with high probability. Multi-arm trials are more efficient than two-arm trials as they compare multiple therapies in a single trial. There has been an increase in the use of adaptive designs, particularly in response adaptive randomization (RAR) and early stopping, to further improve efficiencies in trial design. Designs with a higher probability of participants receiving better treatment and/or the ability to end early can be more efficient and attractive to investigators, participants, and stakeholders, but come with their criticisms. We set out to find the most efficient design for a future study. The purpose of this motivating study is to identify the application of docosah

SUBMITTER: Brown AR 

PROVIDER: S-EPMC12933519 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature