Exploring the anti-diabetic potential of bis-Schiff bases of ibuprofen: insights into the <i>in vitro</i>, molecular docking and density functional theory analyses.

ABSTRACT: Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia resulting from defects in insulin action or secretion. The synthesized bis-Schiff base derivatives of ibuprofen were evaluated for their in vitro α-amylase and α-glucosidase inhibitory activities using acarbose as a standard. Six compounds (13, 12, 14, 10, 9, and 11) exhibited superior dual inhibitory potency compared to acarbose, with IC₅₀ values ranging from 3.85 ± 0.05 µM to 14.47 ± 0.14 µM (α-amylase) and 4.36 ± 0.12 µM to 16.18 ± 0.12 µM (α-glucosidase), representing 1.1- to 4.2-fold enhanced activity. Compound 13 (3,4,5-trimethoxyphenyl) was the most potent, showing 4.2-fold (α-amylase) and 3.8-fold (α-glucosidase) improvement compared to acarbose. Molecular docking and DFT analyses re

SUBMITTER: Ayaz M 

PROVIDER: S-EPMC12933524 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature