Wet-adhesive metabolic hydrogel for osteoimmune-guided extraction socket healing.

ABSTRACT: Dynamic wet interfaces, exemplified by tooth extraction sockets, demand dressings that can maintain firm adhesion despite constant salivary flushing, suction, and mastication while actively guiding tissue regeneration. Conventional hemostatic materials detach easily under these forces, destabilizing clots and impairing healing. Here, we develop a photocurable wet-adhesive metabolic hydrogel (WAM-Gel) that integrates interfacial stability with bioinstructive metabolic signaling. The hydrogel is formed from N-acryloyl glycinamide (NAGA) and acryloyl-6-aminocaproic acid N-hydroxysuccinimide ester (AANHS), which in situ photo-crosslink into a hydrogen-bond-rich, covalently anchored dual network. This architecture provides high compressive strength, considerable burst pressure, an

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12933753 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature