Longitudinal multisource clinical model for early lung cancer risk stratification and screening.

ABSTRACT:

Objectives

Lung cancer is the leading cause of cancer-related mortality worldwide, with poor prognosis largely due to late-stage diagnosis. Current screening methods such as low-dose CT face accessibility and cost barriers in resource-limited settings. This study develops a lightweight multichannel convolutional neural network for lung cancer screening support through longitudinal risk stratification using routine pre-diagnostic healthcare data.

Methods

We conducted a retrospective cohort study using Taiwan's National Health Insurance Research Database, comprising 99 615 individuals (575 lung cancer cases; 99 040 non-cancer controls). Diagnostic codes, medication records and medical orders within a 36-month observation window were extracted. Log-likelihood ratio feature selection was implemented to reduce dimensionality, achieving 99.8% reduction in computational requirements while retaining clinical relevance. A multichannel Convolutional Neural Network (CNN) architecture was designed to process these heterogeneous data modalities simultaneously.

Results

The proposed method achieved an F₁-score of 0.5738, precision of 0.7149, Area Under the Receiver Operating Characteristic Curve (AUROC) of 0.8316 and Area Under the Precision-Recall Curve (AUPRC) of 0.1617, outperforming baseline methods in precision and F₁-score. Ablation studies confirmed that medical orders provide primary predictive value, while medication features contribute limited discriminative signal in the pre-diagnostic phase. SHapley Additive exPlanations analysis revealed that routine healthcare utilisation patterns, rather than cancer-specific features, drive risk stratification.

Discussion

The lightweight architecture enables deployment in resource-constrained clinical environments while maintaining robust performance, offering potential as a preliminary screening tool to identify high-risk individuals for further diagnostic examination.

Conclusion

Efficient deep learning models using routine clinical data can facilitate lung cancer risk stratification and screening, providing a scalable solution for clinical implementation.

SUBMITTER: Chien CH 

PROVIDER: S-EPMC12933799 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature