Association of extraintestinal manifestations and disease severity in paediatric inflammatory bowel disease: a multicentre cohort study.

ABSTRACT:

Objective

Extraintestinal manifestations (EIMs) are common in paediatric inflammatory bowel disease (IBD), often impairing quality of life. Our aim was to assess whether EIMs at diagnosis are associated with disease severity in paediatric IBD.

Methods

We conducted a post hoc analysis from the Hungarian Pediatric IBD Registry (2010-2020), including children with Crohn's disease (CD) or ulcerative colitis (UC). Outcomes (relapse, steroid dependency, biological therapy (BT), surgery) were compared between patients with EIMs at diagnosis and those without, using Kaplan-Meier and Cox regression analyses.

Results

Among 1590 patients, EIMs were more frequent in CD than in UC (25% vs 14%, p<0.0001). In CD, EIMs were linked to earlier steroid dependency (p=0.0047) and BT initi

SUBMITTER: Timar AE 

PROVIDER: S-EPMC12933805 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature