Pulpitis Transiently Affect Hepatic Bone Morphogenetic Protein 9 Expression by Lipopolysaccharide.

ABSTRACT:

Introduction and aims

The connection between oral and systemic diseases is receiving increasing attention. Pulpitis is an infectious disease, and its potential impact on the systemic system deserves further investigation.

Methods

A rat/mouse pulpitis model was utilized to explore the variations in bone morphogenetic protein 9 (BMP9) and lipopolysaccharide (LPS) concentrations within liver tissue and blood. Hepatic stellate cells were cultivated and subsequently stimulated with LPS. Histone H3K9 methylation and associated methyltransferase levels were quantified. G9a function was investigated by the G9a methyltransferase inhibitor UNC0642.

Results

In rats and mice with pulpitis, BMP9 expression initially declined in both the liver and blood, followed by a subsequent in

SUBMITTER: Song T 

PROVIDER: S-EPMC12933815 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature