The ability of relapsing fever <i>Borrelia</i> species to survive in chicken serum <i>in vitro</i> and its correlation to interaction with serum components reactive to a polyclonal anti-complement regulator factor H antibody.

ABSTRACT: Bacteria belonging to the relapsing fever-causing genus Borrelia, are important causes of zoonotic veterinary and human infections. The genus contains both species with a specific avian association and species with a suggested wider host range, including avian hosts. Despite this, existing studies exploring the Borrelia-avian interaction are relatively few. In this short communication, we report on the in vitro survival of eight strains of relapsing fever from seven species in chicken serum and its correlation to bacterial binding of serum components reactive to a polyclonal anti-complement regulator factor H antibody. All tested relapsing fever strains exhibited the capability to survive in chicken serum in vitro. Components of chicken serum reactive to polyclonal anti-factor H antibodies were found to bind to the surface of spirochetes and to whole cell lysates, but this was not mandatory for serum survival.

SUBMITTER: Jakobsson T 

PROVIDER: S-EPMC12933832 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature