Ultrasound-propelled oncolytic biomimetic microbubbles as <i>in situ</i> vaccines reprogram tumor immunosuppressive microenvironment.

ABSTRACT: Oncolytic peptides offer a novel anticancer paradigm by inducing membrane lysis-mediated cancer cell death and subsequent anticancer immunity to overcome tumor heterogeneity and treatment resistance. Despite its promising profiles, the clinical application of oncolytic peptides (such as LTX-315) is hampered by ticklish reasons like rapid plasma clearance, suboptimal biodistribution, and potential toxicity toward normal tissues. Herein, we innovatively engineered an ultrasound-propelled cancer cell membranes-hybridized lipid microbubbles to load oncolytic peptide LTX-315 (LCMBs) for precise and controlled oncolytic therapy. The LCMBs enabled the targeted delivery and stimuli-responsive release of LTX-315 in the tumor site under low-intensity focused ultrasound (US). The high accumulation of

SUBMITTER: Wan L 

PROVIDER: S-EPMC12933863 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature