Characterization and clinical implications of CpG island methylator phenotypes of resistant tumors.

ABSTRACT:

Background

Drug resistance, characterized by high heterogeneity and complex mechanisms, poses a significant challenge in cancer treatment. Stratifying resistant tumors into biologically and clinically meaningful subgroups can improve prognostic evaluation and help guide treatment decisions. However, the DNA methylation-based subtypes of resistant tumors have not yet been comprehensively characterized.

Results

DNA methylation profiles from resistant tumors were retrieved from public database including TCGA and GEO. For each tumor type resistant to a specific treatment drug, consensus clustering based on the most variable methylated probes was conducted to identify the DNA methylation subtypes of resistant tumors. For low-grade glioma (LGG) resistant to Temozolomide, consensus

SUBMITTER: Hou F 

PROVIDER: S-EPMC12933914 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature