Instrumental variable approach to estimating individual causal effects in N-of-1 trials: application to ISTOP study.

ABSTRACT: An N-of-1 trial is a multiple crossover trial conducted in a single individual to provide evidence to directly inform personalized treatment decisions. Advances in wearable devices greatly improved the feasibility of adopting these trials to identify optimal individual treatment plans, particularly when treatments differ among individuals and responses are highly heterogeneous. Our work was motivated by the I-STOP-AFib Study, which examined the impact of different triggers on atrial fibrillation (AF) occurrence. We described a causal framework for "N-of-1" trial using potential treatment selection paths and potential outcome paths. Two estimands of individual causal effect were defined: (i) the effect of continuous exposure, and (ii) the effect of an individual's observed behavior. We addr

SUBMITTER: Qu K 

PROVIDER: S-EPMC12934031 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature