Mspms: an R package and GUI for multiplex substrate profiling by mass spectrometry.

ABSTRACT:

Background

Multiplex Substrate Profiling by Mass Spectrometry (MSP-MS) is a powerful method for determining the substrate specificity of proteolytic enzymes, which is essential for developing protease inhibitors, diagnostics, and protease-activated therapeutics. However, the complex datasets generated by MSP-MS pose significant analytical challenges and have limited accessibility for non-specialist users.

Results

We developed mspms, a Bioconductor R package with an accompanying graphical interface, to streamline the analysis of MSP-MS data. Mspms standardizes workflows for data preparation, processing, statistical analysis, and visualization. The tool is designed for accessibility, serving advanced users through the R package and broader audiences through a web-based interfa

SUBMITTER: Bayne C 

PROVIDER: S-EPMC12934049 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature