A 5-hydroxymethylcytosine-based noninvasive model for acute myocardial infarction in type 2 diabetes: implications in cardiovascular outcomes from a 5-year median follow-up study.

ABSTRACT:

Background

Patients with type 2 diabetes (T2D) are at an increased risk of developing acute myocardial infarction (AMI), yet the role of 5-hydroxymethylcytosines (5hmC) changes in T2D-associated cardiovascular events remains poorly understood. Despite therapeutic advances, patients with T2D who suffer an AMI continue to exhibit markedly elevated cardiovascular risk and poor prognosis, underscoring the need for improved detection and risk assessment.

Methods

We evaluated genome-wide 5hmC modifications in circulating cell-free DNA (cfDNA) for their value as noninvasive biomarkers for AMI in T2D. Genome-wide mapping of 5hmC in plasma cfDNA were obtained using the 5hmC-Seal technique from 225 participants, including 57 T2D patients with AMI (T2D + AMI), and 168 T2D patients with

SUBMITTER: Yang K 

PROVIDER: S-EPMC12934080 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature