Glutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis.

ABSTRACT:

Background

Inducible nitric oxide synthase (iNOS) is a key driver of aberrant angiogenesis in inflammatory conditions and cancer, making it an attractive therapeutic target. Nevertheless, its function can be affected by the complex immune responses and tumor microenvironment (TME). Hence, combinatorial treatment approaches that simultaneously target iNOS and immune-modulatory signaling are strongly recommended for cancer therapy. Moreover, the current iNOS inhibitors are limited by poor pharmacokinetics and a lack of selectivity.

Results

To address these challenges, we developed a glutathione (GSH)-responsive iNOS-inhibiting polymeric prodrug (GRIP) decorated with betamethasone succinate (NP_BeS). These dual-function nanoparticles (NP_BeS) remain stable u

SUBMITTER: Alimoradi H 

PROVIDER: S-EPMC12934088 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature