An integrated multi-omics and network analysis of neutrophil differentiation from initial- to late-stage.

ABSTRACT:

Background

Neutrophil differentiation is a well-orchestrated process that involves coordinated changes in the chromatin accessibility, transcription factor (TF) binding, 3D genome-structure and transcription. However, despite significant advances in understanding the later stages of neutrophil maturation, the initial molecular events that trigger and drive the commitment to neutrophil lineage remain poorly characterized, especially the functional roles of master TFs in orchestrating the earliest stages of lineage specification.

Results

Here, we examine changes in the genome topology, transcriptome, and chromatin accessibility during the neutrophil differentiation process. We demonstrate striking changes in 3D genome structure and chromatin accessibility as early as 4 h after

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12934089 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature