Adult pertussis in the acellular-cell vaccine era: Comparative analysis of pertussis toxin antibodies in hospitalized patients with prolonged cough.

ABSTRACT: In the past two years, pertussis cases in China have reemerged, shifting from infants to older children (≥6 years). In adults, underdiagnosis is common due to symptom overlap with other cough disease and limited testing, highlighting the need for better assessment in prolonged cough cases. Residual serum samples from 589 adults hospitalized with prolonged cough (≥2 weeks) formed the case group, while 589 age-, sex-, and region-matched non-cough patients served as controls. PT-IgG levels, measured via ELISA, indicated past (≥62.5 IU/mL) or recent infection (≥100 IU/mL, within a year). PT-IgG ≥ 62.5 IU/mL was detected in 17.0% of cases vs. 2.7% of controls, and ≥100 IU/mL in 7.3% vs. 1.0%. Cases had a higher median PT-IgG (16.74 vs. 2.50 IU/mL, p < .001). Among cases, those aged 60-69

SUBMITTER: Guo M 

PROVIDER: S-EPMC12934150 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature