Specific role of two NlpC/P60 endopeptidases in cell division and membrane vesicle formation in <i>Deinococcus radiodurans</i>.

ABSTRACT: The bacterial cell wall is composed of peptidoglycan (PG), a sugar polymer cross-linked by short peptide stems. PG determines cell morphology and protects it from environmental stresses. Cell growth and division require a balance between synthesis and hydrolysis of the PG. One class of PG hydrolase is the NlpC/P60 superfamily which is broadly distributed in bacteria, archaea, eukaryotes and viruses. Deinococcus radiodurans, characterized by its extreme radioresistance, is a diderm bacterium with a thick layer of PG located between the inner and outer membrane. D. radiodurans exhibits three NlpC/P60 endopeptidases, their role in morphogenesis and cell cycle remains unexplored. In this work, we investigated the role of each endopeptidase in cell division to assess their specifi

SUBMITTER: Kamara T 

PROVIDER: S-EPMC12934235 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature