ATGL-catalyzed biosynthesis mediates the upregulation of fatty acid hydroxy fatty acids (FAHFA) levels in white adipose tissue with fasting.

ABSTRACT: FAHFAs are a family of bioactive lipids. A subclass of these, palmitic acid hydroxy stearic acids (PAHSAs) have anti-inflammatory and anti-diabetic effects. Adipose tissue PAHSA levels are upregulated with increased de novo lipogenesis and fasting and downregulated with insulin resistance and obesity. Adipose triglyceride lipase (ATGL) regulates FAHFAs through two distinct mechanisms: hydrolysis of triacylglycerol (TG)-containing FAHFAs and catalyzing formation of the ester bond found in all FAHFAs through a transacylase reaction. ATGL mediates the increase of PAHSAs with fasting in white adipose tissue (WAT), but the mechanism for this has not been determined. Here, we show that multiple FAHFAs are dynamically regulated with fasting and short-term refeeding in both perigonadal (PG) and su

SUBMITTER: Santoro A 

PROVIDER: S-EPMC12934275 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature