Dataset Information
A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using <sup>11</sup>C-PE2I PET.
Ontology highlight
ABSTRACT: Background
Scaled Subprofile Modelling using principal component analysis (SSM/PCA) is a multivariate analysis technique primarily used in 18F-FDG PET brain studies to produce disease-specific patterns (DPs) and scalar scores aiding neurological diagnosis. SSM/PCA relies on well-characterized reference groups, posing challenges in real-world clinical datasets where diagnoses may be uncertain. A data-driven ensemble approach may offer a more robust alternative to random sampling when reference groups are unavailable.Objective
To apply SSM/PCA to dynamic 11C-PE2I-PET data for differential diagnosis of parkinsonism using a Monte Carlo cross-validation-inspired framework with ensemble prediction.Methods
Dopamine transporter availability, expressed as the specific binding ratio (SBR) relative to cerebellar gray matter and relative cerebral blood flow (R1) images from 47 healthy controls and 316 patients who underwent dynamic11C-PE2I-PET on a Discovery MI PET/CT scanner were included. Patients had a single most probable diagnosis of Parkinson's disease (PD), dementia with Lewy bodies (DLB), or progressive supranuclear palsy (PSP) based on clinical information and the PET reading. A stratified 80/20 training/testing split was applied, repeated across 100 seeds, to generate DPs used for training ensemble classification models. Classification accuracy was assessed on the test-set.Results
Combining SBR and R1 improved accuracy yielding a balanced accuracy of 90%, with SBR primarily differentiating patients from healthy controls and R1 for differentiating between PD, DLB and PSP.Conclusions
Our results highlight the potential of an ensemble-based SSM/PCA method to assist differential diagnosis of parkinsonism. Future work will focus on including additional atypical parkinsonian disorders.
SUBMITTER: Falk L
PROVIDER: S-EPMC12934278 | biostudies-literature | 2026 Feb
REPOSITORIES: biostudies-literature
Publications
A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using <sup>11</sup>C-PE2I PET.
NeuroImage. Clinical 20260218
<h4>Background</h4>Scaled Subprofile Modelling using principal component analysis (SSM/PCA) is a multivariate analysis technique primarily used in <sup>18</sup>F-FDG PET brain studies to produce disease-specific patterns (DPs) and scalar scores aiding neurological diagnosis. SSM/PCA relies on well-characterized reference groups, posing challenges in real-world clinical datasets where diagnoses may be uncertain. A data-driven ensemble approach may offer a more robust alternative to random samplin ...[more]