Subcortical microglial inflammation is uniquely linked to subpial cortical demyelination in multiple sclerosis.

ABSTRACT:

Background

In multiple sclerosis (MS), pathology of both the subpial cortex and subependymal parenchyma has been strongly linked to compartmentalized meningeal inflammation. The topographical distribution of subpial demyelination can be appraised in vivo using surface-based mapping of magnetization transfer saturation (MTsat) in the cortex with 7T MRI. We combined 7T cortical MTsat mapping with [¹¹C]PBR28 PET molecular imaging of microglia to study the potential influence of subcortical microglial inflammation on cortical pathology.

Methods

Thirty-eight MS patients (median EDSS: 4.0) and 21 healthy controls (HCs) underwent high resolution 7T MRI and [¹¹C]PBR28 PET. Principal component analysis of [¹¹C]PBR28 PET data was used to phenotype pati

SUBMITTER: Thevakumaran R 

PROVIDER: S-EPMC12934281 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature