Longitudinal measurements of inhibitory cognitive performance in patients with schizophrenia and bipolar disorder.

ABSTRACT:

Background

Cognitive impairment is a major determinant of functional outcome in psychotic spectrum disorders. Among cognitive domains, motor response inhibition has received limited longitudinal investigation. The present study examined the temporal course of inhibitory performance and its relationship with dimensional psychopathology in schizophrenia and bipolar disorder.

Methods

Thirty-eight outpatients (23 schizophrenia spectrum, 15 bipolar spectrum) from the e-Prevention project were followed for up to 26 months. At monthly or bi-monthly intervals, participants completed a computerized Go/No-Go task assessing accuracy, response speed and intra-individual variability of response speed. Linear mixed-effects models evaluated the effects of time, diagnosis and longitudinal c

SUBMITTER: Smyrnis A 

PROVIDER: S-EPMC12934289 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature