The role of lipids in mediating the effects of immune cells on Alzheimer's disease risk: A network Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown associations between immune cells, lipids, and Alzheimer's disease (AD), but their specific causal relationships and the mediating role of lipids remain unclear.

Methods

Within a network Mendelian randomization (MR) framework, we first applied two-sample univariable MR to assess the causal effects of immune cells and lipids on AD. Then, multivariable MR was used in mediation analyses to determine whether lipids mediate the effects of immune cells on AD. Finally, reverse MR analyses were performed to minimize potential bias from reverse causation. The inverse variance weighted method was used as the primary estimator.

Results

The analysis revealed that elevated levels of CD33 on CD33dim HLA DR+ CD11b+ and CD33 on CD33dim HLA

SUBMITTER: Yang X 

PROVIDER: S-EPMC12934311 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature