Registry-based randomised phase II study of Enzalutamide versus Abiraterone: assessing cognitive function in eLderly patients with metastatic castration-resistant Prostate cancer (REAL-Pro).

ABSTRACT:

Background

Androgen receptor pathway inhibitors (ARPIs) are commonly used in older patients with metastatic castration-resistant prostate cancer (mCRPC). Treatment selection is informed by considering adverse event (AE) profiles, given that there are no previous randomised phase III comparison trials.

Materials and methods

This prospective registry-based randomised trial utilised the electronic Prostate Cancer Australian Database to collect clinical data. Patients aged ≥75 years who were suitable to receive abiraterone or enzalutamide for mCRPC were randomised to receive either ARPI treatment, stratified by prior docetaxel use. Telephone assessments were conducted at baseline and 12 weeks, including the Blessed Orientation-Memory-Concentration (BOMC) tool, Geriatric Depressi

SUBMITTER: Anton A 

PROVIDER: S-EPMC12934321 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature