Extended follow-up of invasive cervical cancer risk after quadrivalent HPV vaccination: nationwide, register based study.

ABSTRACT:

Objectives

To evaluate the long term risk of invasive cervical cancer after receiving the quadrivalent human papillomavirus (HPV) vaccine, how risk varies by time since vaccination, and to assess the population level impact of HPV vaccination programmes.

Design

Nationwide register based cohort study with up to 18 years of follow-up.

Setting

Sweden, from 1 January 2006 to 31 December 2023.

Participants

926​ 362 girls and women residing in Sweden between 2006 and 2023, born in 1985-88 (opportunistic cohort), 1989-92 (subsidised cohort), 1993-98 (catch-up cohort), or 1999-2001 (school based cohort), and with no previous HPV vaccination or diagnosis of invasive cervical cancer at the start of follow-up.

Main outcome measures

Incidence rate ratios of invasive

SUBMITTER: Wu S 

PROVIDER: S-EPMC12934514 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature