Biomechanical Modification of the Sclera: An Ex Vivo Study on Porcine Eyes.

ABSTRACT:

Purpose

Scleral biomechanics are altered in various ocular pathologies. Modification of sclera biomechanics has been proposed as a potential treatment strategy. This study characterizes the biomechanical effect of collagenase (COL), glyceraldehyde (GAD), microbial transglutaminase (mTG), transglutaminase 1 (TG1), transglutaminase 2 (TG2), and lysyl oxidase (LOX) on ex vivo porcine sclera.

Methods

Tissue biomechanics were assessed by uniaxial tensile testing. Tangent modulus (ET) was calculated from the stress-strain curve. The biomechanical response was analyzed based on dose-response curves. Locally applied treatments to the intraocular, extraocular, and combined intra- and extraocular scleral surface were compared with incubated tissue strips. Treatment safety was investig

SUBMITTER: Ross AKM 

PROVIDER: S-EPMC12934521 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature