PR55α subunit of protein phosphatase 2A supports KRAS^G12D-driven tumorigenesis that requires YAP activation.

ABSTRACT: PP2A holoenzymes account nearly 50% of Ser/Thr phosphatase activities in human cells, yet their roles in oncogenesis remain largely unexplored. A PP2A holoenzyme consists of a catalytic subunit, a scaffold subunit, and a regulatory subunit. We previously reported that PR55α, a PP2A regulatory subunit, supports the tumorigenic and metastatic potential of pancreatic cancer cells, and this is associated with its role in promoting YAP activation, which is essential for tumorigenesis and progression in most solid tumors, including pancreatic cancer. However, the direct role of PR55α in tumorigenesis has not yet been assessed. Using telomerase-immortalized human pancreatic ductal cells (HPNE), this research reveals a mechanism in which PR55α/PP2A cooperates with oncogenic KRAS^G12D to

SUBMITTER: Jenkins CB 

PROVIDER: S-EPMC12934529 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature