Statin Therapy Independently Reduces Mortality and Liver Complications in Patients With Cirrhosis: An Updated Systematic Review and Meta-Analysis.

ABSTRACT:

Background

The role of statins in cirrhosis remains controversial. Historically restricted due to safety concerns, emerging evidence highlights potential pleiotropic benefits, though effects on mortality and decompensation remain uncertain.

Aims

To evaluate the effects of statin therapy on all-cause mortality, hepatic decompensation, hepatic venous pressure gradient (HVPG), and hepatocellular carcinoma (HCC) in cirrhosis.

Methods

We systematically searched major databases until July 2025 for randomised controlled trials (RCTs) and observational studies comparing statin therapy versus non-use in cirrhosis. Random-effects meta-analyses were performed.

Results

The meta-analysis included 25 studies (9 RCTs, 16 observational) with 81,992 patients. Statins reduced al

SUBMITTER: Moraes BF 

PROVIDER: S-EPMC12934547 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature