Role of mitochondrial ribosomal protein L7/L12 (MRPL12) in diabetic ischemic heart disease.

ABSTRACT:

Background

Myocardial infarction (MI) is a significant cause of death in diabetic patients. Growing evidence suggests that mitochondrial dysfunction contributes to heart failure in diabetes. However, the molecular mechanisms of mitochondrial dysfunction mediating heart failure in diabetes are still poorly understood.

Methods

We examined MRPL12 levels in right atrial appendage tissues from diabetic patients undergoing coronary artery bypass graft (CABG) surgery. Using AC-16 cells overexpressing MRPL12 under normal and hyperglycemic conditions we performed mitochondrial functional assays OXPHOS, bioenergetics, mitochondrial membrane potential, ATP production and cell death.

Results

We observed elevated MRPL12 levels in heart tissue samples from diabetic patients with is

SUBMITTER: Rai AK 

PROVIDER: S-EPMC12935059 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature