Enhanced cytotoxic activity of <i>Moringa oleifera</i>-loaded pharmacosomes against neuroblastoma.

ABSTRACT: Moringa oleifera is known for its diverse therapeutic properties, including anticancer effects attributed to its rich phytochemical profile; yet, its poor solubility and stability limit its therapeutic translation. In this study, phospholipid-based pharmacosomal nanocarriers loaded with Moringa oleifera extract (MO) were developed and characterized to enhance its delivery and anticancer efficacy against neuroblastoma. Neuroblastoma is a common pediatric malignancy of neural crest origin with poor prognosis in high-risk cases, highlighting the need for safer and more effective therapeutic strategies. GC-MS analysis of the MO extract revealed diverse bioactive constituents with documented cytotoxic, pro-apoptotic, and antioxidant properties, including polyphenolic acids, flavon

SUBMITTER: Abd Alkader Alabrahim O 

PROVIDER: S-EPMC12935072 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature