MIG-6 Regulates HDAC1-Mediated Angiogenesis and Tumorigenesis in PTEN-Deficient Endometrioid Endometrial Cancer.

ABSTRACT: Endometrioid endometrial cancer (EEC) is the most prevalent gynecological malignancy, yet no targeted therapies are currently approved by the FDA specifically. To identify therapeutic targets for EEC, we performed transcriptomic and proteomic analyses in genetically engineered preclinical cancer models, including uterine-specific Pten-deficient (Ptend/d) mice and Ptend/d mice with additional overexpression of tumor suppressor Mig-6 (Ptend/dMig-6over) mice that develop EEC. Transcriptomic analysis revealed significant inhibition of immune, inflammatory, and angiogenesis pathways with hypoxia-inducible factor-1 (HIF1α) as a key upstream regulator. Interactome and immunoprecipitation analyses identified HDAC1 as a MIG-6-interacting protein that mediates angiogenic signaling in PTEN-deficient

SUBMITTER: Nahar S 

PROVIDER: S-EPMC12935093 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature