Tissue perfusion pressure enables continuous hemodynamic evaluation and risk prediction in the intensive care unit.

ABSTRACT: Treatment of circulatory shock in critically ill patients requires management of blood pressure using invasive monitoring, but uncertainty remains as to optimal individual blood pressure targets. Critical closing pressure, which refers to the arterial pressure when blood flow stops, can provide a fundamental measure of vascular tone in response to disease and therapy, but it has not previously been possible to measure this parameter routinely in clinical care. Here we describe a method to continuously measure critical closing pressure in the systemic circulation using readily available blood pressure monitors and then show that tissue perfusion pressure (TPP), defined as the difference between mean arterial pressure and critical closing pressure, provides unique information compared to oth

SUBMITTER: Chandrasekhar A 

PROVIDER: S-EPMC12935171 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature