Mechanistic insights into triclosan-induced hepatotoxicity: A network toxicology and molecular docking approach.

ABSTRACT:

Background

Triclosan (TCS) is an artificially synthesized broad-spectrum antimicrobial agent, which is widely used in personal care products. It is a new endocrine disruptor and has potential health hazards to human body.

Objective

Based on network toxicology and molecular docking technology, the compounds that may cause hepatotoxicity in triclosan were predicted and the mechanism was discussed.

Method

From April to May 2025, the targets of triclosan were identified using databases such as STITCH, CTD, Swiss Target Prediction, and TargetNet. Additionally, gene targets associated with liver toxicity were identified from the GeneCards and OMIM databases. The intersection of triclosan-targets and liver toxicity-related gene targets was used to identify candidate targets.

SUBMITTER: Liu F 

PROVIDER: S-EPMC12935200 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature