High-throughput screening of drug libraries identifies a new synergistic drug combination for the treatment of retinoblastoma.

ABSTRACT: Retinoblastoma (RB) management often involves the combination of chemotherapeutic agents (e.g., carboplatin and etoposide) and techniques (e.g., chemotherapy and thermotherapy). Chemoresistance and relapse, as well as systemic and ocular toxicities of current retinoblastoma chemotherapeutics necessitate the implementation of alternative drugs. Fewer resources and concern for pediatric cancer hinder drug discovery and development in an effective way. To overcome the obstacle, a drug repurposing strategy without intuition was adopted to identify promising drug candidates that are both cytotoxic and selective towards human RB Y79 cells in vitro and an orthotopic xenograft mice model in vivo. By using high-throughput screening, gemcitabine demonstrated high cytotoxicity in Y79 cells, also pote

SUBMITTER: Tseng PJ 

PROVIDER: S-EPMC12935222 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature