Transcriptomic response of skeletal muscle to acute aerobic versus combined exercise in chronic kidney disease.

ABSTRACT:

Background

Chronic kidney disease (CKD) affects approximately 14% of the UK population and is associated with significant exercise intolerance, partly due to skeletal muscle dysfunction. While exercise is a potential therapeutic strategy, the molecular response of skeletal muscle to exercise in CKD remains poorly understood. This study aimed to characterise transcriptomic changes in skeletal muscle 24 hours after aerobic (AE) or combined aerobic and resistance exercise (CE) in non-dialysis CKD.

Methods

This study utilised muscle biopsies from participants in the ExTRA CKD trial with stage 3b-4 CKD stages 3b-4 (AE: 24 (15-32) ml/min/1.73m2; CE: 25 (19-31) ml/min/1.73m2). Participants (n = 4 per group) were randomised to 12 weeks of thrice-weekly AE or CE. Vastus lateralis ske

SUBMITTER: Baker LA 

PROVIDER: S-EPMC12935244 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature