Genetic polymorphisms of the <i>CDC27</i> gene are associated with susceptibility and outcomes of non-syndromic congenital heart disease: a bi-ethnic case-control study in Chinese populations.

ABSTRACT:

Background

Cell division cycle 27 (CDC27) gene expression is closely associated with the cell cycle and has been implicated in the pathogenesis of congenital heart disease (CHD) in animal models. This study focuses on investigating whether single-nucleotide polymorphisms (SNPs) in the CDC27 gene are associated with CHD and the cardiac remodeling process in the population of Xinjiang, China.

Methods

This study conducted a case-control study including 689 controls and 575 patients with CHD. SNPs of the CDC27 gene were genotyped using an improved multiple ligase detection reaction.

Results

Our study found that the CDC27 rs11570579 polymorphism was significantly associated with CHD susceptibility in the Uyghur population (additive model: aOR =

SUBMITTER: Yuan T 

PROVIDER: S-EPMC12935316 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature